abstract：:The nociceptin receptor (NOP) and its endogenous ligand, nociceptin/orphanin FQ (OFQ), are involved in a wide range of biological functions, such as pain, anxiety, learning, and memory. The zebrafish has been proposed as a candidate to study the in vivo effects of several drugs of abuse and to discover new pharmacolog...

journal_title：Journal of molecular endocrinology

authors： Rivas-Boyero AA,Herrero-Turrión MJ,Gonzalez-Nunez V,Sánchez-Simón FM,Barreto-Valer K,Rodríguez RE

更新日期：2011-03-03 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is synthesized from a precursor, which includes the PACAP-related peptide (PRP; formerly known as GHRH-like peptide). PRP can act as a hypophysiotropic factor in teleosts by stimulating GH secretion. However, no information points to this peptide as a regulato...

journal_title：Journal of molecular endocrinology

authors： Levy G,Degani G

更新日期：2011-03-03 00:00:00

abstract：:Murine double minute clone 2 (MDM2) is a multifunctional protein, which modulates nuclear receptor-mediated transactivation. In this study, we show that MDM2 significantly enhanced estrogen receptor α (ERα) and ERα/specificity protein-mediated transactivation in MCF-7 and ZR-75 breast cancer cells. This was demonstrat...

journal_title：Journal of molecular endocrinology

authors： Kim K,Burghardt R,Barhoumi R,Lee SO,Liu X,Safe S

更新日期：2011-02-15 00:00:00

abstract：:It has been demonstrated that transforming growth factor-β (TGFβ) and other members of TGFβ superfamily play an important role in thyroid proliferative diseases. The deficiencies of SMAD4 are responsible to accelerate the malignant progression of neoplastic lesions in several types of tumors. Therefore, the objective ...

journal_title：Journal of molecular endocrinology

authors： D'Inzeo S,Nicolussi A,Ricci A,Mancini P,Porcellini A,Nardi F,Coppa A

更新日期：2010-10-01 00:00:00

abstract：:The mechanism behind Ca(2)(+) entry into the parathyroid cells has been widely debated, and the molecular identities of the responsible ion channels have not been established yet. In this study, we show that the parathyroid cells lack voltage-operated Ca(2)(+) channels. Passive store depletion by thapsigargin, on the ...

journal_title：Journal of molecular endocrinology

authors： Lu M,Bränström R,Berglund E,Höög A,Björklund P,Westin G,Larsson C,Farnebo LO,Forsberg L

更新日期：2010-05-01 00:00:00

abstract：:Hypothalamic GHRH controls the release of GH from the pituitary gland and also acts as a growth factor in a variety of cancers. The mitogenetic activity of GHRH is exerted through the binding to the pituitary type receptor (pGHRH-R) and its splice variants, mainly SV1. The intracellular signaling pathways that are act...

journal_title：Journal of molecular endocrinology

authors： Barabutis N,Siejka A,Schally AV,Block NL,Cai R,Varga JL

更新日期：2010-02-01 00:00:00

abstract：:Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms by which androgens modulate body composition are largely unknown. Here, w...

journal_title：Journal of molecular endocrinology

authors： Gentile MA,Nantermet PV,Vogel RL,Phillips R,Holder D,Hodor P,Cheng C,Dai H,Freedman LP,Ray WJ

更新日期：2010-01-01 00:00:00

abstract：:Whether insulin, at physiological concentrations, has direct effects on vascular smooth muscle cells (VSMCs) remains controversial. Our aim was to characterize the mechanism for insulin resistance in VSMCs. For comparison, the effects of IGF1 and IGF2 were also studied. Cultured human aortic smooth muscle cells (HASMC...

journal_title：Journal of molecular endocrinology

authors： Chisalita SI,Johansson GS,Liefvendahl E,Bäck K,Arnqvist HJ

更新日期：2009-12-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged during Transfection (RET) proto-oncogene plays a key role in the development of MTC. How...

journal_title：Journal of molecular endocrinology

authors： Cerrato A,De Falco V,Santoro M

更新日期：2009-10-01 00:00:00

abstract：:CRH and its structurally related peptide urocortin (Ucn) are released under stress. Ucn is a potent agonist for CRH-receptor 2 (CRH-R2), which is strongly expressed in rodent heart. Stress induces Ucn mRNA expression in the heart, where it may be cardioprotective. However, increasing evidence indicates that Ucn may al...

journal_title：Journal of molecular endocrinology

authors： Huang M,Kempuraj D,Papadopoulou N,Kourelis T,Donelan J,Manola A,Theoharides TC

更新日期：2009-05-01 00:00:00

abstract：:FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal (hpg) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays...

journal_title：Journal of molecular endocrinology

authors： Abel MH,Baban D,Lee S,Charlton HM,O'Shaughnessy PJ

更新日期：2009-04-01 00:00:00

abstract：:Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) are regarded as complications of gastro-oesophageal reflux disease, although all the factors that contribute to the development of these lesions are unknown. Acid suppressive drugs are widely used for symptomatic therapy of reflux disease but may induce hy...

journal_title：Journal of molecular endocrinology

authors： Beales IL,Ogunwobi OO

更新日期：2009-04-01 00:00:00

abstract：:The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development, tumour suppressio...

journal_title：Journal of molecular endocrinology

authors： Rezgui D,Williams C,Savage SA,Prince SN,Zaccheo OJ,Jones EY,Crump MP,Hassan AB

更新日期：2009-04-01 00:00:00

abstract：:1alpha,25-dihydroxyvitamin D(3) upregulates tumour necrosis factor superfamily member 11 (TNFSF11) that codes for the receptor activator of nuclear factor kappaB ligand (RANKL), and downregulates osteoprotegerin (OPG) expression. We have analyzed the individual effects of polymorphisms in the vitamin D receptor gene (...

journal_title：Journal of molecular endocrinology

authors： Mencej-Bedrac S,Prezelj J,Kocjan T,Teskac K,Ostanek B,Smelcer M,Marc J

更新日期：2009-03-01 00:00:00

abstract：:GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of L-alpha-amino acids, a signaling augmented by the divalent cations Ca(2)(+) and Mg(2)(+). GPRC6A transcripts are detected in numerous mammalian tissues, but the physiological role of the receptor is thus far elusive. Analogously to the clo...

journal_title：Journal of molecular endocrinology

authors： Wellendorph P,Johansen LD,Jensen AA,Casanova E,Gassmann M,Deprez P,Clément-Lacroix P,Bettler B,Bräuner-Osborne H

更新日期：2009-03-01 00:00:00

abstract：:Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T lymphocyte function is well established, the role of this protein in other cell types remains unknown. Given that GRAIL is abundant in the liver, we investigated the pote...

journal_title：Journal of molecular endocrinology

authors： Nakamichi S,Senga Y,Inoue H,Emi A,Matsuki Y,Watanabe E,Hiramatsu R,Ogawa W,Kasuga M

更新日期：2009-02-01 00:00:00

abstract：:Studies have demonstrated that heat shock is associated with alteration in energy metabolism. In this study, we investigated the effect of heat shock on gene expression and secretion of adiponectin and leptin, and gene expression of Hspa2 and Ppargamma in 3T3-L1 adipocytes. Compared with 37 degrees C, adiponectin mRNA...

journal_title：Journal of molecular endocrinology

authors： Bernabucci U,Basiricò L,Morera P,Lacetera N,Ronchi B,Nardone A

更新日期：2009-02-01 00:00:00

abstract：:Androgens play an important role in male reproductive development and function. These steroid hormones mediate their actions by binding to the androgen receptor (AR). Diseases such as androgen insensitivity syndrome, prostate cancer, Kennedy's disease, and infertility can be caused by mutations in the AR. To get a bet...

journal_title：Journal of molecular endocrinology

authors： Kerkhofs S,Denayer S,Haelens A,Claessens F

更新日期：2009-01-01 00:00:00

abstract：:In non-mammalian vertebrates, estrogens are key players in ovarian differentiation, but the mechanisms by which they act remain poorly understood. The present study on rainbow trout was designed to investigate whether estrogens trigger the female pathway by activating a group of early female genes (i.e. cyp19a1, foxl2...

journal_title：Journal of molecular endocrinology

authors： Vizziano-Cantonnet D,Baron D,Mahè S,Cauty C,Fostier A,Guiguen Y

更新日期：2008-11-01 00:00:00

abstract：:Mammary explants can be hormonally stimulated to mimic the biochemical changes that occur during lactogenesis. Previous studies using mammary explants concluded that the addition of exogenous macromolecules were required for mammary epithelial cells to remain viable in culture. The present study examines the survival ...

journal_title：Journal of molecular endocrinology

authors： Brennan AJ,Sharp JA,Lefèvre CM,Nicholas KR

更新日期：2008-09-01 00:00:00

abstract：:The crystal structures of the leucine-rich repeat domain (LRD) of the FSH receptor (FSHR) in complex with FSH and the TSH receptor (TSHR) LRD in complex with the thyroid-stimulating autoantibody (M22) provide opportunities to assess the molecular basis of the specificity of glycoprotein hormone-receptor binding. A com...

journal_title：Journal of molecular endocrinology

authors： Núñez Miguel R,Sanders J,Chirgadze DY,Blundell TL,Furmaniak J,Rees Smith B

更新日期：2008-09-01 00:00:00

abstract：:Intracellular glucocorticoid (GC) receptor (GR) function determines tissue sensitivity to GCs and strongly affects the development of type 2 diabetes and obesity. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mediates intracellular steroid exposure to mouse liver GR by prereceptor reactivation of GCs and is...

journal_title：Journal of molecular endocrinology

authors： Liu Y,Nakagawa Y,Wang Y,Liu L,Du H,Wang W,Ren X,Lutfy K,Friedman TC

更新日期：2008-08-01 00:00:00

abstract：:Cellular changes that affect the androgen receptor (AR) can cause prostate cancer to transition from androgen dependent to androgen independent, which is usually lethal. One common change in prostate tumors is overexpression of the AR, which has been shown to lead to androgen-independent growth of prostate cancer cell...

journal_title：Journal of molecular endocrinology

authors： Hsieh CL,Cai C,Giwa A,Bivins A,Chen SY,Sabry D,Govardhan K,Shemshedini L

更新日期：2008-07-01 00:00:00

abstract：:Tumour necrosis factor superfamily member 11 (TNFSF11) gene, that codes for receptor activator of nuclear factor-kappaB ligand, is one of the candidate genes for the genetic susceptibility to osteoporosis. As variations in the TNFSF11 gene promoter could alter its expression, the aim of the study was to evaluate the f...

journal_title：Journal of molecular endocrinology

authors： Mencej S,Albagha OM,Prezelj J,Kocjan T,Marc J

更新日期：2008-06-01 00:00:00

abstract：:Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabe...

journal_title：Journal of molecular endocrinology

authors： Xu M,Chen X,Yan L,Cheng H,Chen W

更新日期：2008-05-01 00:00:00

abstract：:The chemokine Stromal-derived factor-1alpha (SDF-1alpha) interacts with seven transmembrane (TM) G-protein-coupled receptor (GPR), CXCR4. SDF-1alpha is linked to inflammation, chemoattraction, cancer metastasis, and hematopoiesis. Tachykinin (Tac1) peptides bind seven transmembrane (TM), GPR and are involved in tumor ...

journal_title：Journal of molecular endocrinology

authors： Corcoran KE,Malhotra A,Molina CA,Rameshwar P

更新日期：2008-03-01 00:00:00

abstract：:The somatostatin receptor subtype 2 (sst2) mediates inhibition of hormone secretion and cell proliferation, and modulates neurotransmission. Its expression is widespread in various normal tissues and many malignant cells, and is up-regulated by estrogen in breast cancer cells. This study was undertaken to investigate ...

journal_title：Journal of molecular endocrinology

authors： Kimura N,Takamatsu N,Yaoita Y,Osamura RY,Kimura N

更新日期：2008-02-01 00:00:00

abstract：:Microarray studies have identified many genes that are down-regulated in uterine leiomyoma compared with myometrium, including early growth response gene-1 (EGR1). However, the mechanisms underlying coordinated down-regulation of this gene cohort remain unknown. To address the transcriptional role of EGR1 in leiomyoma...

journal_title：Journal of molecular endocrinology

authors： Ishikawa H,Shozu M,Okada M,Inukai M,Zhang B,Kato K,Kasai T,Inoue M

更新日期：2007-11-01 00:00:00

abstract：:In order to better quantify the molecular mechanisms regulating final oocyte maturation and spawning, complete coding sequences with partially or fully untranslated regions for the steroidogenic enzymes, cytochrome P450 aromatase and 20 beta-hydroxysteroid dehydrogenase, were cloned from ovaries of Atlantic cod (Gadus...

journal_title：Journal of molecular endocrinology

authors： Mittelholzer C,Andersson E,Consten D,Hirai T,Nagahama Y,Norberg B

更新日期：2007-10-01 00:00:00

abstract：:We used the Crm1 inhibitor leptomycin B (LMB) to examine a possible involvement of nuclear export in estrogen receptor alpha (ER) level and function in MCF-7 breast carcinoma cells. As revealed by immunofluorescence microscopy and western blotting with anti-ER antibodies, LMB produced an accumulation of ER in cell nuc...

journal_title：Journal of molecular endocrinology

authors： Nonclercq D,Journé F,Laïos I,Chaboteaux C,Toillon RA,Leclercq G,Laurent G

更新日期：2007-08-01 00:00:00

abstract：:Genetic studies have reported association of a polyglycine-encoding GGN repeat in exon 1 of the androgen receptor (AR) gene with common human traits. The polyglycine tract is located in the transactivating domain of the AR protein, suggesting an effect of repeat length on receptor function. Here, we compare the functi...

journal_title：Journal of molecular endocrinology

authors： Brockschmidt FF,Nöthen MM,Hillmer AM

更新日期：2007-07-01 00:00:00

abstract：:The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired immune deficiency syndrome (AIDS) progression. Transcription from the HIV-1 long terminal repeat (LTR) is a crucial step for vi...

journal_title：Journal of molecular endocrinology

authors： Nevado J,Tenbaum SP,Castillo AI,Sánchez-Pacheco A,Aranda A

更新日期：2007-06-01 00:00:00

abstract：:Chemotactic cytokines (chemokines) are small secreted proteins that control leukocyte trafficking in immune organs. Chemokines which are induced in the brain during conditions of inflammation play a role in the local immune response. Recently, it has been established in the rodent brain that distinct chemokines and ch...

journal_title：Journal of molecular endocrinology

authors： Stumm R,Höllt V

更新日期：2007-03-01 00:00:00

abstract：:Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may p...

journal_title：Journal of molecular endocrinology

authors： Ackermann AM,Gannon M

更新日期：2007-02-01 00:00:00

abstract：:The human progesterone receptor (PR) is a ligand-dependent transcription factor and two isoforms, (PRA and PRB), can be distinguished. PROGINS, a PR polymorphic variant, affects PRA and PRB and acts as a risk-modulating factor in several gynaecological disorders. Little is known about the functional consequences of th...

journal_title：Journal of molecular endocrinology

authors： Romano A,Delvoux B,Fischer DC,Groothuis P

更新日期：2007-02-01 00:00:00

abstract：:The type 1 form of 17beta-hydroxysteroid dehydrogenase (17betaHSD1) was the first isoform to be identified and is capable of converting estrone to 17beta-estradiol. This study was aimed at characterizing the molecular structure of the equine 17betaHSD1 gene and cDNA, as well as its molecular regulation during human ch...

journal_title：Journal of molecular endocrinology

authors： Brown KA,Sayasith K,Bouchard N,Lussier JG,Sirois J

更新日期：2007-02-01 00:00:00

abstract：:A new full-length cDNA (ZFOR4) that encodes an opioid receptor has been isolated from the teleost zebrafish. The encoded polypeptide is 375 amino acids long and shows high sequence similarity to other delta-opioid receptors, including ZFOR1, the other delta-opioid receptor from zebrafish previously characterized by us...

journal_title：Journal of molecular endocrinology

authors： Pinal-Seoane N,Martin IR,Gonzalez-Nuñez V,Marron Fernandez de Velasco E,Alvarez FA,Sarmiento RG,Rodriguez RE

更新日期：2006-12-01 00:00:00

abstract：:Soluble guanylyl cyclase is a cytosolic enzyme which catalyzes conversion of GTP to the second messenger cyclic GMP. The transcriptional regulation at the promoter levels of four soluble guanylyl cyclase subunits, termed alpha1, alpha2, beta1, and beta2, is largely unknown. In this study, we identified the transcripti...

journal_title：Journal of molecular endocrinology

authors： Jiang Y,Stojilkovic SS

更新日期：2006-12-01 00:00:00

abstract：:The expression of genes encoding corticotropin-releasing factor (CRF) and its receptor type-1 (CRF1R) and type-2alpha (CRF2R) has been studied in the brain of rats with streptozotocin (STZ)-induced diabetes and adrenalectomy (ADX). Diabetic rats had a lower body weight compared to control rats. Food and water intake w...

journal_title：Journal of molecular endocrinology

authors： Huang Q,Timofeeva E,Richard D

更新日期：2006-10-01 00:00:00

abstract：:The mechanisms underlying sex determination and differentiation in fishes are labile in response to environmental parameters. Sex-specific phenotypes are largely regulated by sex steroids, and the inhibition or the stimulation of aromatase can reverse sex as well as alter secondary sexual characteristics in fishes. Am...

journal_title：Journal of molecular endocrinology

authors： Orlando EF,Katsu Y,Miyagawa S,Iguchi T

更新日期：2006-10-01 00:00:00